In summary, currently available in vivo and in vitro models have improved our understanding of wound healing process. A complex process that integrates multiple cell types and repair phases, including inflammation, proliferation, re-epithelialization and remodeling. A variety of in vivo skin healing models, including incisional, excisional, burn models combined with in vitro migrations assays and histopathological, immunological and biochemical methods have provided valuable information regarding the basic mechanisms of wound healing. It is of high importance to develop optimal strategies in the future to help patients with adverse wounds or related diseases, such as psoriasis.